What is Mucosamin?

Targeted treatment for mucositis

Mucosamin helps to treat and relieve the symptoms of mucositis, caused as a result of cancer therapies such as chemotherapy and radiotherapy.

Mucosamin protects the healthy oral mucosa, whilst providing pain relief and promoting wound healing of painful lesions.

What is mucositis?

Mucositis describes inflammatory and/or ulcerative lesions of the mucosa, which often result from chemotherapeutic agents or radiation.1 It is a common complication of cancer treatments, which can have significant, and sometimes dose-limiting, consequences.2

Oral Mucositis (OM)

OM is an acute inflammatory and ulcerative complication of the mucosal membrane that commonly occurs during cancer therapy. OM is one of the side-effects3 of cancer treatment and can result from systemic chemotherapy, radiation therapy, or a combination of the two.

What is Mucosamin?

  • Protects
  • Relieves
  • Heals

The Mucosamin range contains sodium hyaluronate and amino acids, which helps to treat and relieve the symptoms of mucositis. Mucosamin protects the healthy oral mucosa, whilst providing pain relief and promoting wound healing of painful lesions.

How does Mucosamin work?



Helps to maintain mucosal integrity⁴

Forms a barrier to help protect the oral mucosa5


Hydrates and modulates osmotic balance6

Creates a film to cover exposed nerve endings7

Helps reduce inflammation8

Protects local mucosa from free radicals to prevent tissue injury4,9


Supports epithelial wound repair9,10

Dry mouth


  • Hyaluronic acid (HA) has mucoadhesive properties and binds to proteoglycans on the surface of oral epithelial cells, through the formation of hydrogen bonds and electrostatic interactions.11


  • HA binds to water at the mucosa through the formation of hydrogen bonds with water molecules6,12
  • Increased levels of HA are associated with greater saliva production13
  • HA modulates tissue hydration and osmotic balance⁶


  • Due to the mucoadhesive and hydrating properties of HA, moisture is retained at the mucosa to provide relief of symptoms.

The role of hyaluronic acid (HA)

  • Key component of connective tissue9
  • Serves as scaffold for extracellular matrix (ECM) proteins14
  • Acts as an antioxidant – protects tissues from damage caused by reactive oxygen species12
  • Supports wound healing9,10

The role of amino acids
(glycine, L-proline, L-leucine
and L-lysine HCl)

  • Support the role of Hyaluronic Acid5
  • Assist in the process of wound repair9


Peterson, D. et al. on behalf of the ESMO Guidelines Committee Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up, Annals of Oncology, Volume 26, Issue suppl_5, September 2015, Pages v139–v151, https://doi.org/10.1093/annonc/mdv202 (Accessed May 2023).

Oral Cancer Foundation. Mucositis. https://oralcancerfoundation.org/complications/mucositis/ (Accessed May 2023).

European Oncology Nursing Society. Oral mucositis guidelines. Available from: https://www.ons.org/pep/mucositis?display=pepnavigator&sort_by=created&items_per_page=50 (Accessed May 2023).

Cirillo, N. et al. (2014) A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo. J of Cell Phys.

1010461483 v 4.0 April 2023 Data on File

Mariggio M.A. et al. (2009) Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and amino acids. Int J Immunopathol Pharmacol, 22: 485-492

Campos, M. et al. Oral mucositis in cancer treatment: Natural history, prevention and treatment (review). Mol Clin Oncol. 2014: 2; 337- 340

Kapoor, P. et al. (2011) Topical hyaluronic acid in the treatment of oral ulcers. Indian J Dematol. 56(3): 300-302

Colella, G. et al. (2010) Efficacy of a spray compound containing a pool of collagen precursor synthetic amino acids (L-Proline, L-Leucine, L-Lysine and Glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis. Int J Immunopathol Pharmacol, 23(1):143-15

Mucosamin Mouthwash and Oral Spray IFUs

Walicova, V. et al. (2016) The influence of hyaluronan addition on thickness, weight, uniformity of mass and water content of mucoadhesive films. Czech and Solvak Pharmacy, 65(3); 94-98

Manasa, M. et al. (2012) A Review of Hyaluronic Acid. Int. J. Res. Chem. Environ, 2(4); 6-11.

Higuchi, Y. et al. (2009) Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study. Biomedical Research, 30(1): 63-68

Colella, G. et al. (2009) Amino acid-enriched sodium hyaluronate enhances keratinocyte scattering, chemotaxis and wound healing through integrin B1 dependent mechanisms. The Journal of Stomatological Investigation, 3: 21-29.

Adverse events should be reported. Reporting forms and information can be found at: www.mhra.gov.uk/yellowcard

Adverse events should also be reported to Aspire Pharma Ltd on 01730 231148.