Mucositis describes inflammatory and/or ulcerative lesions of the mucosa, which often result from chemotherapeutic agents or radiation.1 It is a common complication of cancer treatments, which can have significant, and sometimes dose-limiting, consequences.2
OM is an acute inflammatory and ulcerative complication of the mucosal membrane that commonly occurs during cancer therapy. OM is one of the side-effects3 of cancer treatment and can result from systemic chemotherapy, radiation therapy, or a combination of the two.
The Mucosamin range contains sodium hyaluronate and amino acids, which helps to treat and relieve the symptoms of mucositis. Mucosamin protects the healthy oral mucosa, whilst providing pain relief and promoting wound healing of painful lesions.
Helps to maintain mucosal integrity⁴
Forms a barrier to help protect the oral mucosa5
Hydrates and modulates osmotic balance6
Creates a film to cover exposed nerve endings7
Helps reduce inflammation8
Protects local mucosa from free radicals to prevent tissue injury4,9
Supports epithelial wound repair9,10
Reference 1.
Peterson, D. et al. on behalf of the ESMO Guidelines Committee Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up, Annals of Oncology, Volume 26, Issue suppl_5, September 2015, Pages v139–v151, https://doi.org/10.1093/annonc/mdv202 (Accessed July 2024).
Reference 2.
Oral Cancer Foundation. Mucositis. https://oralcancerfoundation.org/complications/mucositis/ (Accessed July 2024).
Reference 3.
European Oncology Nursing Society. Oral mucositis guidelines. Available from: https://www.ons.org/pep/mucositis?display=pepnavigator&sort_by=created&items_per_page=50 (Accessed July 2024).
Reference 4.
Cirillo, N. et al. (2014) A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo. J of Cell Phys.
Reference 5.
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Reference 6.
Mariggio M.A. et al. (2009) Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and amino acids. Int J Immunopathol Pharmacol, 22: 485-492
Reference 7.
Campos, M. et al. Oral mucositis in cancer treatment: Natural history, prevention and treatment (review). Mol Clin Oncol. 2014: 2; 337- 340
Reference 8.
Kapoor, P. et al. (2011) Topical hyaluronic acid in the treatment of oral ulcers. Indian J Dematol. 56(3): 300-302
Reference 9.
Colella, G. et al. (2010) Efficacy of a spray compound containing a pool of collagen precursor synthetic amino acids (L-Proline, L-Leucine, L-Lysine and Glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis. Int J Immunopathol Pharmacol, 23(1):143-15
Reference 10.
Mucosamin Mouthwash and Oral Spray IFUs
Reference 11.
Walicova, V. et al. (2016) The influence of hyaluronan addition on thickness, weight, uniformity of mass and water content of mucoadhesive films. Czech and Solvak Pharmacy, 65(3); 94-98
Reference 12.
Manasa, M. et al. (2012) A Review of Hyaluronic Acid. Int. J. Res. Chem. Environ, 2(4); 6-11.
Reference 13.
Higuchi, Y. et al. (2009) Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study. Biomedical Research, 30(1): 63-68
Reference 14.
Colella, G. et al. (2009) Amino acid-enriched sodium hyaluronate enhances keratinocyte scattering, chemotaxis and wound healing through integrin B1 dependent mechanisms. The Journal of Stomatological Investigation, 3: 21-29.
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