What is radiation proctitis?2
Radiation proctitis is a radiation induced rectal mucositis and is defined as an inflammatory process of the rectal mucosa that can occur almost immediately or up to 3 months after the initiation of radiotherapy. Symptoms of acute radiation proctitis include burning pain sensations, diarrhoea, nausea, cramps, tenesmus, urgency, mucous discharge, and minor bleeding.
Mucosamin Rectal Gel Clinical Summary3
193 patients undergoing radiation treatment for prostate carcinoma were randomised to prophylactic treatment with Mucosamin® rectal gel (n = 100) or control with non-topical steroid therapy (n=93) for prevention/treatment of actinic proctitis.
Mucosamin® was applied in the evening from the first day of treatment, up until two weeks after cessation of treatment as per the device instructions. All patients had weekly check-ups during the period and had a final follow-up 3 weeks after cessation of treatment. Four patients died during the study as a result of disease progression or cardiovascular events.
Considering an average follow-up of 24 months, the treatment group experienced significantly fewer G1 and G2 toxicities (p<0.05) compared with the control group and more G0 rectal toxicities were experienced in the treatment group (85 vs 71).
Compared with oral steroidal treatment, Mucosamin® was significantly more effective and reduced the number of incidences of actinic proctitis (inflammation of the lining of the rectum).